Human papilloma virus (HPV) external genital infections have several clinical forms that can coexist, namely: cutaneous common warts, flat warts, veruciform epidermodysplasia, focal epithelial hyperplasia, bowenoid papulosis, external genital cancer. Recent studies underline the explosive increase in the prevalence of these infections, HPV being one of the most frequent sexually transmitted viruses - approximaely 630 million cases worldwide according to WHO 2010 statistics. The diagnosis of the external genital infection with HPV includes the direct examination of the patient, the laboratory diagnosis - histopathological, molecular and serologic diagnosis - and the differential diagnosis. A prompt and complex diagnosis helps in the initiation of adequate treatment, in the prevention of future relapses, as well as in the reduction of the huge infectious reservoir represented by the HPV contaminated persons.