Dermatitis herpetiformis Duhring-Brocq: Clinical, physiopathological and therapeutical aspects
Dermatitis herpetiformis (DH) Duhring-Brocq is an inflammatory cutaneous disease with a chronic-relapsing course, pruritic polymorphic lesions and typical histopathological and immunopathological findings.
Patients with DH have an associated gluten-sensitive enteropathy (GSE) that is usually asymptomatic. The diagnosis is established clinically, histologically, immunopathologically [direct immunofluorescence (DIF)] and serologically [IgA anti-tissue transglutaminase antibodies (anti-tTG) and IgA endomisial autoantibodies (EMA)]. A gluten-free diet (GFD) is the treatment of choice for patients with dermatitis herpetiformis. Dapsone and/or other drugs should be used during the period until the GFD is effective.
We present the case of a 62 years old female, diagnosed by means of a skin biopy with dermatitis herpetiformis Duhring-Brocq. Clinical and histopathological aspects of the lesions are described and presented in the article. The particularities of our case are the age of onset (sixth decade of age), the clinical aspect that may suggest (eventually) the association of an excoriated prurigo, but two serial biopsies taken from different skin lesions didn’t confirm this diagnosis and the aspect of residual lesions (atrophic scars).