Lichen planus is a morbid chronic inflammatory condition of unknown etiology and has skin anifestations and/or mucous, the oral mucosa is most frequently concerned. Pathogenesis, partially elucidated, is the subject of debate and a current research topic. Accepted assumptions concerning pathophysiological involving of antigen-specific mechanisms, some nonspecific mechanisms and of autoimmunity.

The results of recent research documenting complex immunological nature of the disease but also the potential relationship between it and systemic inflammation, metabolic syndrome and cardiovascular risks.