Bullous pemphigoid is a bullous autoimmune disease model characterized by humoral and cellular response directed against against BP180 and BP230. Blisters formation is initiated by anti-BP180 antibodies and mediated by complement activation, recruitment of inflammatory cells, release of proteolytic enzymes and direct interference with adhesion function of the antigens.

The involvement of exogenous factors in the pathogenesis of bullous pemfigoidului requires exposure epitopes, previously „protected“ and formation of the autoantibodies. Knowledge of the pathogenesis of disease facilitate the development of new therapeutic strategies for bullous pemphigoid.