Autoimmune bullous skin diseases are characterized by autoantibody production against structural proteins of the skin and/or mucous membranes. The accurate diagnosis requires clinical evaluation, histologic and immuno-pathologic findings. The aim of our study was to evaluate the sensitivity of clinical, histologic and immunologic findings for the diagnosis of pemphigus, bullous pemphigoid and dermatitis herpetiformis. In this study, we prospectively investigated 70 patients with pemphigus, 59 patients with bullous pemphigoid and 12 patients with dermatitis herpetiformis. The sensitivity of clinical and histological diagnosis for pemphigus, bullous pemphigoid and dermatitis hepetiformis was 52.8%, 52.5% 41.6% and 78%  50.8%, 50%, respectively. Comparing the per-formance of the clinical and histological diagnosis with ELISA, the sensitivity of ELISA was higher. We conclude that clinical assessment and routine histologic evaluation  must be complemented by direct/indirect immuno-fluorescence and ELISA to improve the diagnostic performance.