A case of keratosis punctate palmoplantaris
Punctate palmoplantar keratodermas (also called keratosis punctate palmoplantaris Buschke–Fischer–Brauer type) is a very rare genodermatosis, with autosomal dominant transmission, characterized by numerous small, asymptomatic, hyperkeratotic papules and plaques that are irregularly distributed on the palms and soles’ surface, bilaterally. Two loci for punctate palmoplantar keratoderma were recently found to be located on 8q24.13–8q24.21 and 15q22–15q24. However, no genes for this disease have been identified to date. Associations with different types of cancers were described, without having been demonstrated a certain connection between these.  It still doesn’t exist a reliable treatment method that can totally eliminate the lesions or prevent the appearance of new hyperkeratoses.
We present the case of an 87 years old patient, with punctate palmoplantar keratodermas (PPPK), with family members (mother, sisters, daughter) also affected by PPPK. In our case, the disorder developed only in feminine gender and with occasional associations with malignancies (patient’s mother presented cervical carcinoma, and patient’s daughter developed breast carcinoma).