Clinical trials and experimental
Correlation between Pasi and Dlqi at patients with psoriasis vulgaris: Study of 104 cases
Lately, a special attention was directed to the psychological effects of various skin disorders, including psoriasis, and their influence on quality of life.
We made a retrospective study on a group of 104 patients with psoriasis vulgaris.
Objective: The purpose of this study was to appreciate the severity of psoriasis using PASI and DLQI scores and evaluation of concordance between the 2 scores.
Patients and methods:
Our study group included 104 patients diagnosed with psoriasis in Dermatology Clinic of Craiova during 2012. Appreciation of disease severity by the physician was based on PASI score. For understanding the effect of psoriasis on quality of life we used the standard questionnaire, the DLQI score calculation. The data were statistically analyzed by using the SPSS 17.0 program, statistical coefficient Spearman and non-parametric test Mann-Whitney U.
Our group included 55 women and 49 men. 61% were from the urban area. Patients were aged between 14-80 years old with a mean age of 53.04. The average for PASI score was 7.58 (minimum 0.8, maximum 49) and for DLQI was 11.10 (minimum 1, maximum 30). Using Spearman coefficient we found a strong correlation between PASI and DLQI (rs = 0.533, p = 0.001). We also noted a statistically significant correlation between DLQI and psychic burdens at patients with extensive psoriasis (p<0.002).
We found no significant correlations between the DLQI and environment provenance, age or sex of patients. Comparative analysis of the two scores revealed discordance between PASI and DLQI score in 14 cases. In 13 patients we noted high DLQI values (> 10), while PASI was in range of 0.8 to 5.8. Of those 13 patients, 10 of them presented psoriasis lesions skin lesion at the exposed areas (hands, facies, scalp, neck region).
It is confirmed that the locations of psoriasis on the hands, face and scalp, although smaller in extent, are more stigmatizing for the patient with important or very important impact on quality of life.
Discordance between DLQI (high) and PASI (low) is more common in females and in the urban area. We consider this discordance as secondary to the different level of perception of disease by women and men and the consequence of complex socio-professional relationships in the urban area.