Keratoacanthoma is a cutaneous lesion, characterised by rapid growth and spontaneous involution, occurring most commonly on the sun-exposed skin areas of middleaged and elderly people.
Multiple keratoacanthomas were described as part of genetic syndromes (generalised eruptive keratoacanthomas of Grzybowski, disseminated multiple keratoacanthomas of the Ferguson-Smith type, keratoacanthomas of Witten and Zak) as a result of different types of traumas, prolonged exposure to chemical carcinogens (tars, resins) or
secondary to other dermatoses (post-herpes zoster, discoid lupus erythematosus, psoriasis, pemphigus foliaceus,lichen planus, atopic dermatitis, acne conglobata, vitiligo etc.).
We present the case of a 36-year-old female patient, who came to the clinic for multiple lesions with an exophytic verrucous surface, associated with erythematous and hypopigmented plaques located on the sun-exposed areas, which had started approximately 18 months before.
Biopsies were performed for both types of lesions that evidenced keratoacanthoma-type changes and respectively discoid lupus.
Under treatment with medium potency dermocorticoids (for lupus), and keratolytic creams and cryotherapy (for keratoacanthomas), the evolution was favourable, with partial remission of lesions.