Mucous Membrane Pemphigoid (MMP) is the clinical phenotype of a group of chronic autoimmune subepidermal bullous diseases that predominantly affects the mucous membranes and occasionally the skin. The disease affects women more than men, with an incidence ratio of 2 to 1. The average incidence age is between 60 and 80 years. We present the case of an elderly female patient that was admitted in our clinic with oral and ocular mucous lesions. The disease onset took place over 3 years ago through lesions in the oral cavity. Based on the clinical examination, on the histopathogenical examination and on direct immunofluorescence, the diagnostic of mucous membrane pemphigoid was set. The patient followed only a topical treatment with dermatocorticosteroids and the disease evolved with symblepharon and with the almost complete occlusion of the left eyelid.