Worldwide, numerous epidemiological studies have
indicated a significant increase in the incidence of skin
and oral premalignant lesions preceding squamous cell
carinomas, which are among the most frequent and
aggressive types of neoplasms detected in the last three
decades. Although specialists find such lesions relatively
easy to diagnose, patient survival and quality of life are
not significantly improved even with expensive invasive
treatment involving excision. This study provides a
statistical analysis regarding the prevalence of cutaneous
squamous cell carcinoma in premalignant lesions
characteristic of actinic keratosis, Bowen’s disease and
keratocanthoma, compared to the occurrence of the same
type of carcinoma in oral lesions specific to leukoplakia,
oral lichen planus and actinic cheilitis. The data comes from
the Anatomical Pathology and Morgue Service at the „St.
Spiridon” Emergency Clinical Hospital in Iasi and was
collected over a period of five years (2013–2018). The results
indicate an increased incidence of squamous cell carcinoma
in oral premalignant lesions compared to those affecting the
skin, in which case de novo developments are predominant.
The study thus points to the hightened risk of malignant
transformation in precancerous and oral lesions, and it
prompts us to draw attention to the importance of early
diagnosis before the onset of clinical symptoms.