Clinical cases


Introduction: Multinucleate cell angiohistiocytoma (MCAH) is a rare benign vascular tumor.

Clinical case: A 32-year-old patient is examined for multiple asymptomatic brownish papules, ranging in size from 2 to 4 mm, located on the forehead. Histopathological examination revelead a normal epidermis, with a rich dermis vascularization and with the presence of mononucleate histiocytes and rare multinucleate giant cells. Immunohistochemistry was positive for CD31, CD34, factor VIII, CD68, factor XIIIa and vimentin. A diagnosis of
MCAH was established.

Discussions: MCAH represents a tumor due to a benign vascular proliferation. It affects mostly women and it presents as multiple papules located mainly on the dorsal side of the hands. The etiopathogenesis of MCAH remains unknown, suggesting the fibriblastic origin of this tumor. The slow spread and localised evolution of this tumor makes the treatment unnecessary.

Conclusion: The diagnosis of MCAH is mainly useful in excluding other disorders, particularly Kaposi sarcoma.