Our study, based on data from the literature in recent years, looks at a number of aspects of the epigenetic changes encountered in psoriasis. DNA methylation, histone alterations (methylation, acetylation) and microRNA changes were considered.
The selection criterion was the frequency of certain types of epigenetic changes encountered in psoriasis and their association with known elements in the patogeny of psoriasis. The epigenetic changes presented interfere with the main pathogenic processes in psoriasis: the proliferation of keratinocytes and the immunological changes in the level of T lymphocytes, with the alteration of the cutaneous immune response. The main changes in DNA methylation, acetylation and histone methylation and changes in various types of microRNAs are presented.
Our study focused on explaining the epigenetic mechanisms and the impact that these changes have on the pathogenesis of psoriasis. Where possible, the impact of these epigenetic changes on the clinical course of psoriasis and on the response to therapy has also been presented.
At present, epigenetics opens a new field of research in the pathogenesis, clinical evolution and therapy of psoriasis.