Summary

Chronic venous insufficiency (CVI) is a progressive condition often associated with recurrent, non-healing leg ulcers that significantly impact a patient’s quality of life. Conventional therapies often provide suboptimal results, leading to the exploration of regenerative approaches such as platelet-rich fibrin (PRF). This article presents the case of a 75-year-old female patient suffering from a right leg ulcer for over 30 years, who underwent five sessions of PRF therapy, with documented dramatic improvement over the course of treatment. This study highlights the potential of PRF as an effective therapeutic option for chronic venous ulcers.