Summary

The Kaposi’s sarcoma is a vascular neoplasia mainly related to the HIV infection, with an increased incidence among these patients. In the general population, it has an incidence of 0.02% in Europe and 3-9% in Africa and it can reach up to 34% among the HIV-positive patients.

We present the case of a 74-year HIV-negative heterosexual male patient diagnosed with Kaposi’s sarcoma on the thigh while being monitored for chronic kidney failure.

The challenges were represented by the diagnosis difficulties, the differential diagnosis during the progress and, last but not least, the establishment of a therapeutic strategy appropriate to the case.