Clinical trials and experimental
LDH role in stadialization of malignant melanoma
Cellular enzymes are proved to be very important in appreciation of neoplastic disease phenomenas. In this category we include AST, ALT, GGT, CK, LDH.
Cutaneous melanoma represents one of the malignancies with significant deterioration of cellular enzymes, with notable differences depending on the invasion degree locoregional or at distance.
Tissue LDH activity correlates with the metabolic needs of tumor cells and blood supply. LDH activity is increased in samples with high density of tumor vessels. It is assign prognostic semnification for LDH according with tumor thickness, Clark level, presence of ulceration, vascular invasion and installation of PTH indepndente hypercalcaemia.
LDH is useful in staging melanoma with visceral metastases.