Erythema annulare centrifugum (EAC) is a figurate erythema with unknown etiology that may be associated with underlying diseases. We describe a case of a 57-yearold man who developed slightly itching erythematous papules on the thigh, which evolved slowly into annular, arcuate and polycyclic lesions with one trailing scale inside erythematous borders. The histological examination, performed on the border of one lesion, showed an epidermal spongiosis and perivascular lymphohistiocytic infiltrate in the upper dermis. Physical examination of oral cavity revealed a noduloulcerative lesion localized on the right lateral side of the tongue and the histology showed a squamous cell carcinoma. Results of routine laboratory studies were normal. Direct skin immunofluorescence was negative. Treatment with topical corticosteroids was unsuccessful. After the surgical treatment of the carcinoma, cutaneous lesions spontaneously disappeared. This case suggests that tongue squamous carcinoma may induce EAC.