Bullous pemphigoid is an autoimmune skin disease that occurs mainly in the elderly. The incidence ranges from 2.5 to 43/1.000.000 and the mortality is two times greater than for general population. The most important risk factors and comorbidities are the neurological disorders (Parkinson’s disease, multiple sclerosis, stroke, epilepsy, dementia, major cognitive impairments, unipolar and bipolar disorders), malignant diseases, pulmonary embolism, bedridden condition, diabetes mellitus, drugs

(neuroleptics, diuretics, oral antidiabetics), old age, male gender, exposure to sunlight and high temperature.