Kaposi sarcoma (KS) is an angioproliferative condition
of multifactorial etiology. Human herpes virus 8 infection
is necessary, but not sufficient for the development of KS.
Various genetic, social, immunologic and endocrine factors
also play a role. KS encompasses four clinical subtypes:
classic (sporadic) KS, endemic KS that occurs in Sub-
Saharan Africa, epidemic KS, which develops in patients
with human immunodeficiency virus (HIV) infection and
iatrogenic KS, associated with the chronic use of
Unlike KS arising in HIV-pozitive patients, there is no
generally accepted staging system or treatment guideline
for classic KS. No systemic treatment is specifically
approved for this form of the disease and randomized trials
comparing drug efficacy are lacking, therefore the
management of these patients often represents a real
challenge for clinicians.
We present the case of a 61 year-old HIV-negative male
patient with no personal history of malignancy or
immunosuppression diagnosed in our clinic with rapidly
progressive classic KS with generalized cutaneous lesions
and oral mucosa involvement and discuss the treatment
strategies in such cases.