Summary

Pemphigus vegetans represents a chronic autoimmune pathology within the bullous skin disorders, being one of the rarest clinical variants of pemphigus vulgaris. Due to its potentially fatal nature, the therapeutic management of patients with pemphigus vegetans always requires a multidisciplinary approach, especially due to the unpredictable nature given by the hyperactive immune status. This case presentation concerns a patient presenting to our clinic with intertriginous vegetative plaques with peripheral pustular clusters, with clinical improvement after administration of low-dose prednisone. The patient subsequently returns for recurrence of the bullous pathology, the lesions being clinically compatible with the classic form of pemphigus vulgaris, on second presentation.