Summary

Cervico-facial skin cancers currently represent a major therapeutic challenge due to the functional and aesthetic impact associated with the affected anatomical region. Although surgical excision remains the standard treatment, a subset of patients requires complex reconstructive procedures and/or associated oncological management. Early identification of these cases is essential for optimizing therapeutic strategies.
A narrative review of the literature was conducted using the PubMed and Google Scholar databases, analyz-ing studies evaluating predictive factors associated with tumor aggressiveness and the need for complex surgery.
Clinical factors such as tumor size and localization in high-risk anatomical areas (nose, eyelids, lips) are frequently associated with extensive surgical interventions. Histopathological characteristics, including perineural invasion, poor differentiation, and positive surgical margins, significantly influence treatment complexity. Systemic inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio and C-reactive protein, may play an emerging role in the assessment of tumor severity.

The integration of these factors may contribute to the development of predictive models useful for multi-disciplinary decision-making and optimization of patient management.