General reviews
Intervention of oxidative stress in ethiopathogenesis of atopic dermatitis – review
Atopic dermatitis is a skin disease resulting from complex interactions between genetic and environmental factors, characterized  by a defective skin barrier function, with reduced filaggrin expression in the skin. There is described a large number of immunological and nonimmunological abnormalities in atopic dermatitis patients, in skin and also in serum, and in the present are many teories and studies about ethiopathogenesis of this frequent desease, mainly in pediatric group.

AD is associated with elevated serum immunoglobulin-especially IgE-levels and sensitization to variety of inhalant, food, and microbial allergens, and peripheral blood eosinophilia.

Recently the researchers focus on the implication of oxidative stress (OS) in ethiopathogenesis of atopic dermatitis. Reactive oxygen species (ROS) interacts with numerous structures, but the major cellular targets of ROS are membrane lipids, proteins, nucleic acids, and carbohydrates. The studies suggests that ROS play a crucial role in the initiation and progression of various diseases, mostly in atopic dermatitis and psoriasis vulgaris, and the researchers demonstrated this, by determination in serum or in tissues the markers of oxidative stress The conclusion that increased oxidative stress are involved in the pathophysiology of childhood AD, can indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.