The skin is the largest multi-functional organ in the body, its appearance generally reflecting the general health status. Normal skin contains high levels of vitamin C, with levels comparable to other body tissues and well above plasma levels. Vitamin C is involved in the formation of the skin and collagen barrier in the dermis and plays a physiological role in the skin against oxidation, in the fight against wrinkles and protection against UV radiation. Vitamin C can be applied topically, although its effectiveness depends on the formula of the cream or serum used, the concentration and the condition of the skin at the time of application.