Diffuse melanosis cutis (DMC) is a rare presentation
of metastatic melanoma characterized by a progressive bluegrey
discoloration of the skin and mucous membranes.
A 60-year-old female patient is consulted for diffuse
brown-grey discoloration of the skin located on the chest
and the left upper limb which appeared 2 months ago and
had a progressive evolution. The personal history of the
patient shows a malignant melanoma operated on 8 months
ago and currently with skin and liver metastases.
DMC is the progressive discoloration of the skin and
mucous membranes in metastatic malignant melanoma.
The release of melanin from melanoma metastases and its
phagocytosis by dermal histiocytes is currently recognized
as the cause of DMC. DMC prognosis is poor.