Summary

Psoriasis vulgaris is one of the most common forms of psoriasis. This is a chronic, autoimmune, immunologically mediated skin condition. Genetic and environmental factors are involved in the pathogenesis of the disease, and recent studies demonstrate that histone mutations play an impor-tant role in the occurrence of inflammation, T cell differen-tiation and keratinocyte proliferation, thus reaching the con-clusion that understanding the molecular mechanism could lead to the development of new therapeutic targets [1].

From a clinical point of view, the lesion is described as a well-defined erythematous plaque, covered by whitish-pearl scales that detach easily [2]. We will present the case of a 47-year-old patient who, from a histopathological point of view, presents all the characteristic changes for psoriasis vulgaris.